Lists and tuples are both used to store collections of items in Python, but they have some key differences: Mutability: Lists are mutable, meaning you can change, add, or remove items after the list has been created. Tuples are immutable, meaning once a tuple is created, it cannot be altered in any way (no item can be added, removed, or changed). Syntax: Lists are defined using square brackets []. Example: my_list = [1, 2, 3] Tuples are defined using parentheses (). Example: my_tuple = (1, 2, 3) Use cases: Lists are preferred when you need a collection of items that may change throughout the program, such as a list of tasks or items in a shopping cart. Tuples are used for fixed collections of items, such as coordinates (x, y) or configuration settings that shouldn’t change. Performance: Tuples are generally faster than lists because they are immutable and thus require less memory and processing time.