Vantaggi
San Diego is nice, Torrey Pines campus is very pleasant. A lot of talented scientist to work with. Pay is alright, but I notice a lot of scientists struggling to afford San Diego nonetheless. La Jolla is about as unnaffordable as it gets so you more/less have to commute no matter where you live. 9x80 means every other friday off, and well you get to live near the beach if you are in San Diego, so that is actually super nice.
Svantaggi
Procurement and beurocracy seems optimized to frustrate engineers and stifle progress. Management seems unable to track budgets, risk averse and not open to change. IT is a joke, and tele-working is only tacitly approved and unfortunately not well supported by their archaic IT systems. 401(k) vesting slow pension? is that even worth anything? Overhead rates are crazy high, which basically means labor consumes hours from a project like no other, so it's hard to fund R&D appropriately. Flying F35s overhead are noisy :)