Vantaggi
I had an incredibly disappointing experience working for the Cancer Support Community. Instead of helping patients day to day, I mostly fielded requests from higher-ups who would freak out anytime the CEO would ask them for something. This created a very toxic working environment where these individuals would take out anger, stress and frustration at lower level employees who often had nothing to do with the projects or tasks that had been assigned - to the point that almost everyone in my department quit within a span of a year or so.
Svantaggi
Unfortunately, I don't think my particular experience was uncommon; I would hear from many of my colleagues that Senior Leadership would set unrealistic expectations for different departments on items like grant deliverables, fundraising and other initiatives.